Genetics: Master Regulator or Master of Disguise?

Ovarian Hyperstimulation Syndrome, the Master of Disguise?

The use of IVF has risen dramatically over the past 10 years and with this the complications of such treatments have also risen. One such complication is ovarian hyperstimulation syndrome with which patients can present acutely to hospital with shortness of breath. On admission, a series of blood tests are routinely performed, including the d-dimer. We present a case of a 41-year-old lady who h...

mTOR: The Master Regulator

Themammalian targetof rapamycin (mTOR)kinase integratescues fromnutrientsandgrowth factors, acting as a nexus point for cellular signals to control growth,metabolism, and longevity. Deregulation ofeitherofmTOR’s twocomplexes,mTORC1ormTORC2, leads todiseasesofmetabolism, including cancer and diabetes. In this issue’s Select, insights into the extent of mTOR’s oncogenic capabilities come to light...

What is a Master Regulator?

Copyright: © 2013 Chan SSK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The term “master regulator” or “master regulatory gene” was first coined by Susumu Ohno over 30 years ago for a “gene that occ...

Interleukin-12: A master regulator

Early resistance to pathogens requires a swift response from NK cells. In 1989, Giorgio Trinchieri identified an NK growth factor and activator, later called interleukin-12 (IL-12). This discovery helped reveal the regulatory link between innate and adaptive immunity.

The Master Regulator of Immunity to Infection